Pipeline

A Pipeline Built Around Reelin Biology

Avendia is building a portfolio of therapeutic programs designed to harness reelin signaling across neurological and neuropsychiatric diseases characterized by impaired synaptic function and plasticity.

Our programs span small-molecule and gene therapy modalities, allowing us to select the approach best suited to each disease.

Development path

Programs moving through discovery and development

A pipeline built around one biology, approached through multiple modalities.

Program

Indications

Modality

Progress

Discovery

IND-Enabling

Phase 1

Phase 2

AVTX-101

CIAS

Gene therapy

IND-Enabling

AVTX-201

AS, AD, TLE

Small molecule

Discovery

Programs

Two complementary ways to harness reelin

AVTX-101

Reelin Gene Therapy

Gene Therapy | Preclinical

Our gene therapy platform uses an engineered functional reelin minigene designed to provide sustained reelin signaling while overcoming the size limitations of conventional AAV vectors.

The approach enables targeted expression of functional reelin biology in disease-relevant brain regions and is being explored for disorders where durable restoration of reelin signaling may provide meaningful therapeutic benefit.

Lead indication: Cognitive impairment associated with schizophrenia (CIAS)

AVTX-201

Reelin Pathway Activators

Small Molecule | Discovery

We are developing brain-penetrant small molecules designed to activate reelin pathway signaling and reproduce key downstream effects of reelin in a practical, orally administered therapy.

Our discovery program is initially focused on disorders characterized by synaptic dysfunction and impaired cognition, with opportunities across neurodevelopmental, neuropsychiatric, and neurodegenerative disease.

Initial focus: Fragile X syndrome and other disorders of synaptic dysfunction

One biology, multiple opportunities

Across our pipeline, the therapeutic modality may change, but the underlying strategy remains the same:

Harness reelin biology to restore the synaptic signaling, plasticity, and circuit function required for a healthy brain.

Discuss a partnership